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McMartin Preschool Trial Essay Example | Topics and Well Written Essays - 500 words

McMartin Preschool Trial - Essay Example The caution in the image separated from the sexual maltreatment charge by the people in question, they additionally professed to have seen flying, went in tourist balloon, some different cases by the casualties were that they experienced an underground passage. The most diverting case by the casualty was that on-screen character Chuck Norris mishandled him. After truly exploring the speculations given by the youngsters, there was no significant proof to back such claim. A clashing objective for this situation is refered to when an observer who had before under the watchful eye of the legal dispute confessed to be intellectually flimsy, the casualty is evaluated through the investigator and the aftereffect of his psychological status is managed to have been brought about by the occasions of the preliminary. He proceeds in asserting that Raymond Bucker was explicitly attacking schoolchildren and was equipped for flying. Legislative issues assume a job for this situation when the underlying examiner Mr. Glenn Stevens utilizes his situation to impact the legal dispute by shaping the victim’s proclamation, the guardians and instructors assume a job in figuring their children’s articulation during the meeting. The guard group together scrutinized the unwavering quality of such a demonstration could happen to numerous understudy furtively without no one having a trace of what is happening for such a significant stretch of time. The nearness of the media at the court as they attempt to catch each and every insight concerning the sex embarrassment that hit the pre-school likewise made the circumstance to be such a tremendous outrage. The investigator denied the safeguard lawyers group some fundamental analytical data that could help the guide their proof. The guard lawyers changed the public’s feeling by contending that a significant wrongdoing caused was by the media to offer an input survey concerning Buckey since he merited a reasonable preliminary at the courtrooms. The other issue was the fruitful evacuation of an appointed authority through a court movement. This caused people in general to have another view looking into the issue. The investigator, press

7 Reasons Why You Dont Want to Miss Writing.ie

7 Reasons Why You Dont Want to Miss Writing.ie As a self-described complete online magazine, Writing.ie has a vast collection of writing resources for writers across genres and around the globe, although its seat of operations is in Dublin, Ireland. Additionally, it offers an events calendar that is absolutely free for authors wishing to announce a literary event or book launch. That, combined with a Resources Page updated often and weekly make the site a useful bookmark for any writer looking for tips, inspiration, marketing outlets, or even the chance to Tell your own story to like-minded authors who access the site daily.The site is established and run by Vanessa Fox OLoughlin, one of Irelands leading literary scouts and former consultant and presenter for WritersWebTV, bringing free, live, online workshops to writers worldwide.In case these details alone are not temptation enough to visit and bookmark the site, here are seven reasons why if youre a writer, you dont want to miss all that Writing.ie has to offer.Writing.ie is a website full of great blogs across several genres and topics related to the writing process and industry.#1. Kate Dempseys Poetic License blogAs one of many guest blogs published on the site, Kate Dempseys Poetic License blog has much to offer writers interested in the art of poetry. It primarily focuses on competitions and publishing opportunities open to poets across a scope of topics and highlights interesting calls for poems both in the U.K. and around the world. For example, this call for submissions for poems about scientists experience announces the opportunity for writers, who find themselves at that strange intersection of science and poetry, to submit their work to a paid anthology entitled Spectral Lines. Although the submission deadline has passed for this particular work, it highlights some of the fascinating opportunities for poets that the blog offers. If youre a poet, its incredibly helpful to know whos looking for your poems and where to send them. If youre a poet in the Dublin area, or the U.K., this is an opportunity you certainly dont want to miss.#2. Hazel Gaynors Carry On Writing blogAs an acclaimed New York Times, USA Today and internationally bestselling author of five novels, Hazel Gaynors debut post, A Beginning and an End, is a great taste of the kind of honest approach she takes in the blog. Heres a quote from it:Im starting to think publishing deals dont really exist, that theyre just myths, the stuff of legend; about as simple to track down as the Ark of the Covenant or the golden snitch.Being an aspiring writer is no easy thing, as any aspiring writer will tell you. Its a lonely, frustrating occupation, riddled with potential for disappointment and despair but â€" and heres the thing â€" with the benefit of hindsight, Ive come to the conclusion that the rejections and close-shaves have made me more determined than ever to succeed. Of course, Id be lying if I said I hadnt thrown the occasional strop on the way to reaching this co nclusion, or curled up on the sofa in a deep rejected-author malaise, unable to speak to anyone, let alone turn on the laptop or pick up a pen, but Im pleased to have reached this conclusion all the same.Hazel Gaynor#3. Louise Phillipss Crime Scene blogIf you write crime or thriller novels, Louise Phillipss Crime Scene blog is for you. Ranging from her lists of Delicious Reads of Irish Crime Fiction books to calls for submissions for Crime novelists, this blog offers information about new books in the genre that have launched, writing conferences and courses, and tips for writers looking to sharpen their crime writing skills. She also offers writing tips and advice for the genre, which can be a great help for anyone looking to break into the industry with their own crime novel.#4. Olivia Hope and Niamh Garveys Flourish Blogs about writing for childrenWritten and curated by Olivia Hope and Niamh Garvey, Down the Rabbit Hole by Flourish and Blogs offers fascinating explorations of th e genre for anyone interested in writing and publishing childrens books. As an example article, Uncomfortable Childrens Books is an examination of the question of what topics are safe for childrens literature. In it, Garvey writes:This is a generation where mental health problems are beginning younger and younger in children. Childhood anxiety, depression and low self-esteem are on the increase. There is a tendency to panic, to think we must protect our children and teenagers from any hardship, to helicopter around them dropping cotton wool at their feet and shaded glasses on their eyes in case they see something unpleasant. They mustnt read that book, where people starve to death, where people die violently, where families are ripped apart, because it will make them sad. And yet, those same children and teenagers are allowed online alone, where more real-life danger lies than the in woods down the road at night.Niamh GarveyIn addition to their thoughtful criticism, this writing due include within their blog childrens book events, new releases, lists of must-reads, and more. As a parent and a writer, I found this blog to be an intriguing and thoughtful read, even though I dont plan to publish in the childrens book genre.#5. Tara Sparlings The Lighter Side blog offers satire and humorIn this blog about book humor, selling trends, marketing and character stereotype follies, Tara Sparlings writing lifts the spirits of her readersâ€"often by stating the obvious on a not-so-obvious path to writing a bestseller. For example, in her post, Who Are You NOT Writing For This Year?, she takes a satirical approach to the all-important writers audience and offers a handy list of all the people you are definitely NOT writing for in 2019. Included on this list are: The cool kid in your class you asked out when you were 15, your ex-spouse, your current spouse, your next spouse, and book reviewers, among others.In another post, You Think 5-Star Reviews Are So Great? Think Again , she asks:Youre certain you want to award 5 stars to this? The highest accolade of them all? This is truly one of the best books youve ever read? Its better than the last 20 books you read and the 20 you read before that?No it isnt. Stop 5-starring like its the 1980s. Give it the solid and absolutely fine 3 it deserves.Tara Sparling#6. Derek Flynns SongBook blog about writing from a musicians perspectiveAs an Irish writer and musician, Derek Flynn has much to say about the connections and inspiration he draws from music, including an ongoing series like this one with interviews of various authors asking about how music has shaped and inspired their writing.Other articles approach literature and writing through music-related concepts, such as this piece titled Literary One Hit Wonders, which discusses famous authors known only by one book. He writes:Of course, when we mention literary one hit wonders, most people will think of Harper Lee and To Kill A Mockingbird, possibly the most famous example (and well ignore the dubious release of Go Set A Watchman). But there are some otherâ€"probably equally as famousâ€"examples. There is, of course, JD Salinger, author of Catcher in the Rye, who subsequently wrote only a handful of short stories and novellasâ€"no more novelsâ€"and gave his last interview in 1980.But while Lee and Salinger chose not to write any more novels, there are others who died before getting the chance to write more, leaving us wondering what might have been.Derek FlynnFlynn also writes of local publishing opportunities or jobs available in the industry, as well as competitions and anthologies seeking submissions.#7. Resources for writersFinally, and as mentioned earlier, the websites section for Resources for writers is packed with valuable information and links to sources writers can use throughout the drafting, editing, publishing and marketing phases of their writing journey.The Resources tab of the site offers links to sources writers can us e throughout the entire process of writing, from first draft to marketing the published work.In the Resources submenu, there are links to the following directories or sources, with additional submenus within each:Services for writersEssential guidesGetting publishedBetter fiction guidesBetter nonfiction guidesWrite for stage and screenBetter poetry guidesDeveloping your craftNational Emerging Writers Program (NEWP)Final takeawayWhile many of the literary events, book signings, and course offerings showcased in writing.ie are for the Dublin, Ireland and Greater U.K. area, there are parts of the site and blogs that provide great sources for writers around the globe. The section I found most helpful as a writer is the Writing Competitions under the Magazine menu. It was chock full of calls for submission, competitions, anthology notices, and publishing opportunities for writers of all genres, and included important information such as deadlines, how to submit your manuscript, and links to the main website for each entity seeking writers or submissions. Ill be using it in the coming months to seek out publishing opportunities and I hope youll be equally as excited about the excellent opportunities that are available.

How Much Did Medicine and Treatment Progress (Change and...

How much did medicine and treatment progress (change and continuity) between 1350 and 1750? In medicine there were many things that changed and some that stayed the same between 1350 and 1750. Initially I will be looking at medicine and treatment in the Ancient World as a prelude to its importance during the Renaissance period, and also the influence it may have had in the Middle Ages. During Ancient times, cure and prevention of illness and disease were not very well developed – people would blame their ill health on Gods, witches, demons or other supernatural causes. They had many theories, such as God punishing them for their sins. The Ancient Greeks began to believe that illnesses had a natural cause – in about 400 BCE, a doctor†¦show more content†¦After 300 CE, Romans officially converted to Christianity, and this thoroughly encouraged people to think illness and disease had natural rather than supernatural causes. Roman doctors were encouraged to expand their knowledge of the human anatomy, which also helped medical understanding progress – however, they still could not carry out dissections. Claudius Galen was an Ancient Roman born in about 129 CE in Greece. He believed the theory of the Four Humours and wrote many books based on this theory, which were to be used by generations to come. He developed the Theory of Opposites – when the four humours became unbalanced, he would give something opposite to the humour that was in excess. An example of this is that if a patient had phlegm (which he associated which hot and dry), they would eat cold food – such as cucumber – drink lots of water and stand out in the rain. Unlike previous and future periods in time, the Ancient Romans believed strongly in personal hygiene. They had public baths in every town and city, and would conduct business there, sending up to two hours a day in them. Canals and aqueducts were designed to carry water to the people in towns, as well as having fresh water and drains. Sewers were cleaned by rainwater, which prevented them for blocking up. All this made a massive change to people’s health as they were much more hygienicShow MoreRelated_x000C_Introduction to Statistics and Data Analysis355457 Words   |  1422 Pagesgraduated from Iowa State University with a major in mathematics and, while acquiring graduate degrees at the University of Iowa, concentrated on statistics, computer programming, psychometrics, and test development. Currently, he divides his duties between teaching and evaluation; in addition to teaching, he is the assessment facilitator for the Cedar Rapids, Iowa, Community Schools. In his spare t ime he enjoys reading and hiking. He and his wife have a daughter, Anna, who is a graduate student in CivilRead MoreMedicare Policy Analysis447966 Words   |  1792 Pagestoday’s health care system, while repairing 6 the aspects that are broken. 7 (3) INSURANCE 8 REFORMS.—This division— (A) enacts strong insurance market re- 9 forms; 10 (B) creates a new Health Insurance Ex- 11 change, with a public health insurance option 12 alongside private plans; 13 (C) includes sliding scale affordability 14 credits; and 15 (D) initiates shared responsibility among 16 workers, employers, and the Government;

Islam- Misunderstood Religion - 564 Words

Introduction Islam is indeed a misunderstood and misrepresented religion in the West. It is for any seeker of the truth who might once have wondered what the religion of Islam is all about, who Allah is, what ultimate goal of man’s existence is. These questions and many others come up on different occasions but are brushed aside for various reasons. When we consider the way so many generations in the West were instructed in the religious problems facing humanity and admit the ignorance in which they were kept about anything related to Islam. Hence, Islamic ideals remain unclear from the vast majority of non-Muslims. However, it will open before you a new dimension of thinking and enable you to realize the importance of your role as a human being in this universe and the relationship between you and our Creator, God, the All Mighty Allah. It presents Islam to you in a nutshell and provides straightforward answers to many questions about Islam and about its credibility. Islam Islam is a believe that there is only one God (Allah), religious tradition that developed in the Middle East in the 7th century C.E. Islam, which literally means surrender or submission, was founded on the teachings of the Prophet Muhammad as an expression of surrender to the will of Allah, the creator and sustained of the world. The Quran, the sacred text of Islam, contains the teachings of the Prophet that were revealed to him from Allah. Essential to Islam is the belief that Allah is the oneShow MoreRelatedIslam: The Misunderstood Religion1879 Words   |  8 Pagesï » ¿ISLAM: The Misunderstood Religion Islam is probably the most misunderstood and misinterpreted religion in the world. This misfortune can be traced back to the day of crusades when Islam was portrayed as a barbaric and pagan religion in the western society. Unfortunately, this misconception prevailed in the western society and hence Islam became to be associated with various misconceptions, false stories, and biased accounts that became part of scholarly articles and authentic histories. HoweverRead MoreThe Misunderstood Religion of Islam609 Words   |  2 PagesIslam is perhaps the supreme misunderstood religion today, among non-Muslims and among some of the Muslims themselves. There are both historical and modern influences that might clarify this misconception of Islam within certain rings in the West. One should start with the fact that Islam, represented historically as the Ottoman Empire man Empire, occupied parts of Europe, which had certainly not occurred to European civilization before. Then there were the Crusades, which was Christendom attemptingRead More The Media and Mass Misinterpretation of Islam Essays893 Words   |  4 PagesThe Media and Mass Misinterpretation of Islam As the cross is the symbol of Christianity, the Star of David the symbol of Judaism, the Crescent Moon and Star are supposedly the symbols of Islam. Islam at its core is a peaceful religion, which like many other religions over the ages has at times been misunderstood not only as to the values it preaches, but also in relation to its core beliefs. Although in today’s post September 11th world Islam and its followers, who are also known as MuslimsRead MoreJihad Is A Symbol Of Destruction And Terrorism909 Words   |  4 PagesArguably the most misunderstood term in the religion of Islam, Jihad could mean one of two things: a struggle for or against something or a Holy War against a nation. The idea of Jihad came about when Prophet Muhammad (peace be upon him), most praised and recognized Prophet of Islam, wanted to spread Islam. Today, Jihad is a symbol of destruction and terrorism. It is frequently seen in the headlines of Western media as a demeaning term meaning an all-out explosive battle has been ensuing betweenRead More Thomas W. Lippmans Understanding Islam Essay1224 Words   |  5 PagesThomas W. Lippmans Understanding Islam Thomas W. Lippman gives an introduction to the Muslim world in the book Understanding Islam. He has traveled throughout the Islamic world as Washington Post bureau chief for the Middle East, and as a correspondent in Indochina. This gave him, in his own words, sharp insight into the complexities of that turbulent region. However, the purpose of the book is not to produce a critical or controversial interpretation of Islamic scripture. It is insteadRead MoreReligion1264 Words   |  6 PagesMisconceptions about Islam – A personal perspective Islam may be the most misunderstood religion in the United States. The impression that majority of non-Muslim Americans have is usually obtained through the media which typically represent Islamic countries or groups in the middle of a Holy War. These wars are usually waged by Islamic Fundamentalist who use terrorism and other violent acts to get their messages across giving Islam a negative reputation. Because of the lack of understandingRead MoreThe Misconceptions About Women in Islam Essay1326 Words   |  6 PagesAbout Women in Islam While people in the west think that women in Islam are oppressed, they do not know that Islam liberated women from oppression. There are many people who have opinions about the religion of Islam, but mostly about the women who follow it. Westerners have this idea that women in Islam are disrespected, mistreated and oppressed. In actuality, these allegations are incorrect. Women in Islam have rights and are not oppressed. The veil is widely misunderstood and many do notRead MoreA Discussion Of Faith Rose Surrounding The World Trade Center1630 Words   |  7 PagesMarch 22nd, a question of faith rose surrounding the sanctity of the Islamic faith. In an article meant to expose answers to this very question John Kasich brings up a point that when people claim France is at war with Islam, they actually should be referring to radical Islam. This point pulled further controversy as those who were not Islamic began to wonder if the faith condoned suicide bombings in the name of ex pelling infidels and bringing the coming of the Caliphate. Another case mentionedRead MoreReflection Paper for Inside Islam638 Words   |  3 PagesReflection Paper Two On the film Inside Islam Submitted to: Prof. Elma M. Lumantas Submitted by: Cresinte Gumilao Subject: History 3 Day and Time: T-Fr 4:00-5:30 School: MSU-GSC Date: March 10, 2011 Part 1. Summary Inside Islam’s background comes from this often misunderstood faith back to its tradition origins before and within the Hebrew Bible, also providing information about on how the religions central constituents helps spread Islam religious belief throughout the world. ThisRead MoreDoes the Media Correctly Portray Islam? Essay861 Words   |  4 Pagesrecent survey, a television network randomly asked people what came to mind when they heard the word Islam (Boston Globe 2005). The majority of the responses were 9/11, terrorists, suicide bombers, Saddam Hussein, and other things along those lines. This may have reinstated the opinions of those who thought poorly of Islam, and already believed it to be a United States hating terrorist religion. Now I see these fallacies even more clearly because I too had similar beliefs; but after taking a course

Biol 130 First Midterm Notes Free Essays

Unit 1 – Introduction to the Cell Robert Hooke – built the first microscope (30x magnification); viewed slices of cork called cellula (little rooms). Antoni Van Leeuwenhoek – worked with glass huge improvement in quality of lenses nearly 300x magnification became possible first to observe: * single-celled organisms â€Å"animalcules† * protists from pond water * bacteria from his mouth – â€Å"father of microbiology† * blood cells * banded pattern in muscle cells * sperm from †¦ 1830s – Compound microscope – improved magnification and resolution and allowed visualization of objects less than 1 ? . 1000-1500x magnification Beginning of Cell Theory Robert Brown (botanist) – noticed that every plant cell contained a round structure called it ‘kernel’-nucleus Matthias Schleiden (another botanist) – all plant tissues are composed of cells; embryonic plant always arose from a single cell Theodor Schwann (zoologist) – similar observations in animal cells; recognition of structural similarities btw plants and animals! * Cell Theory formulated by Schwann Cell Theory 1. We will write a custom essay sample on Biol 130 First Midterm Notes or any similar topic only for you Order Now all organisms consist of one or more cells 2. he cell is the basic unit of structure for all organisms 3. added 20 years later: all cells arise only from pre-existing cells fact (scientific) – an attempt to state our best current understanding, based on observations and experiments(valid only until revised or replaced) Steps in Scientific Method 1. make observations 2. use inductive reasoning to develop tentative explanation (hypothesis) 3. make predictions based on your hypothesis 4. make further observations or design and carry out controlled experiments to test your hypothesis 5. nterpret your results to see if they support your hypothesis Theory – a hypothesis that has been tested critically under many different conditions andby many different investigators . using a variety of different approaches. By the time an explanation is regarded as a theory it is widely accepted by most scientists in the cell * the â€Å"solid ground† of science: evolution, germ the ory, cell theory *If a theory is thoroughly tested and confirmed over many years by such large numbers of investigators that there is no doubt of its validity †¦ it may eventually be regarded as a law. Gravity, laws of thermodynamics, laws that govern behaviour of gases ‘Strands’ of Cell Biology 13 cytology 1600s Hooke looks at cork Leeuwenhoek looks at lots of things 1800s Brown notes nuclei bio-chemistry synthesis of urea in lab fermentation done by cells! glycolysis Krebs cycle every cell comes from a cell Schleiden Schwann formulate cell theory electron microscopy stains dyes genetics Mendel, pea plants DNA chromosomes chromosome theory 1930s DNA double helix DNA sequencing Dolly the sheep! nano-technology! genetic code Light Microscopy: Bright field – light passes through specimen, contrast is slow and specimen is hard to see Phase contrast – contrast is changed by changing light in microscope DIC – uses optical modifications to change contrast between cell and background – due to density differential Staining – stain used to visualize cell and components, only some stains can be used on living cells 14 bright field phase contrast DIC unstained (sperm cells) stained blood cells tissue – small intestine Fluorescent Microscopy – fluorescent dyes bind to protein or DNA to see where they are in cells – tracks movement Electron Microscopy(Scanning Transmission): SEM – scan surface of specimen to form image by detecting electrons from outer surface. Good surface images TEM – forms image from electrons passing through specimen therefore fine details of internal organelles 16 SEM TEM Basic Properties of Cells: * are highly complex and organized * atoms molecules macromolecules (organelles ) enclosed in plasma membrane * use the same ‘genetic program’ Central Dogma * DNA RNA protein * are capable of reproducing themselves * must first replicate genetic material acquire and use energy (â€Å"bioenergetics†) and carry out a variety of chemical reactions (â€Å"cellular metabolism†) * have many processes that are highly conserved at the molecular level * membrane structure, genetic code, ATP synthesizing enzymes, actin filaments, eukaryotic flagella, †¦ * engage in many mechanical activities * transport of materials in/out, within * assembly and disassembly of structures * motility / movement * respond to environmental signals * move away or toward stimuli * respond to hormones, growth factors, etc * are capable of self-regulationâ€Å"homeostasis† most evident when control systems break down; defects in DNA replication, DNA repair, cell cycle control Two Classes of Cells – karyon = nucleus Prokaryotic Cells: lack of nucleus, NO CYTOSKELETON(very small), membrane bound organelles. Mostly unicellular. Bacteria and Archaea. Single, circular strand of DNA(fewer proteins). Cell wall in addition to PM 1-10 uM in diameter. 2 types: 1. Eubacteria – all have cells walls except for mycoplasma(resistant to antibiotics that target cell wall synthesis). Mycoplasma(smallest) Cyanobacteria (largest and most complex). 2. Archaeabacteria – all have cell walls and are known as extermophiles, occupy broad range of habitats, halophiles=salty, acidophiles=acid, thermophiles= hot. Eukaryotic Cells: 10x larger than prokaryotic cells, membrane bound nucleus/organelles. More complex DNA due to histones/proteins. 4 groups: 1. Protists- very diverse group – mostly single cells; algae, water molds, slime molds, protozoa 2. Fungi – single cell(yeast) or multi-cellular(mushrooms) and have cell walls. Heterotrophs; depend on external source of organic compounds 3. Plant cells- multi-cellular and have cell walls. . Animals- multi-cellular, no cell walls and are heterotrophs Cytoplasm – everything between plasma membrane and nuclear membrane, includes all membrane-bound organelles (except nucleus) Cytosol – only fluid component Endomembrane system – internal membranes that are either in direct contact or connected via transfer of vesicles (sacs of membrane). including: nuclea r envelope / membrane, endoplasmic reticulum (ER), Golgi apparatus, lysosomes, vacuoles Nucleus – stores genetic information Endomembrane System – creates intracellular compartments with different functions. Endoplasmic reticulum (ER; rough, smooth), Golgi apparatus, lysosomes. Mitochondria – generate energy to power the cell Chloroplasts – capture energy from sunlight, convert to carbohydrate Cytoskeleton – regulates cell shape, movements of materials within the cell, movement of the cell itself Flow of Traffic in EMS – Rough ER: synthesis of proteins for – export (secretion) – insertion into membranes – lysosomes Golgi apparatus: collection, packaging distribution Lysosomes * cell ‘stomachs’ have enzymes that can digest †¦ * all 4 classes of biological macromolecules worn-out organelles (mitochondria replaced every 10 days) * material brought into cell by phagocytosis Phagocytosis – plasma membrane engulfs smaller molecule and then called phagosome. Lysosome takes it in and digests, small particles are releases into the cytoplasm. Autophagy – lysosome digests a damaged organelle, small particles are relea sed into cytosol. mitochondria (all eukaryotic cells) and chloroplasts (plant cells): * contain DNA that encodes some (but not all) of their own proteins * have unusual double layers of membranes Origin of Eukaryotic Cells: Endosymbiont Theory * once believed that eukaryotes evolved gradually, organelles becoming more and more complex * now accepted that early eukaryotes originated as predators * certain organelles (mitochondria, chloroplasts) evolved from smaller prokaryotes engulfed by larger cell * later chloroplasts and the ability to perform photosynthesis Symbiosis – Mutual Advantage advantage to host cell: * aerobic respiration (aerobic bacteria mitochondria) * photosynthesis (cyanobacteria chloroplasts) advantage to bacteria: * protected environment supply of carbon compounds from host cell’s other prey Evidence Supporting Endosymbiont Theory mitochondria and chloroplasts †¦ * are similar size to bacteria, reproduced by fission like bacteria * have double membranes, consistent with engulfing mechanism * have their own ribosomes, which resemble those of prokaryotes rather than eukaryotes in terms of size, composition and sensitivity to antibiotics * have their own genomes, which are organized like those of bacteria last but not least: * are genetically similar to proposed ‘parent’ bacteria rather than ukaryotic cells Cytoskeleton important in: * cell shape * cell motility * movement / position of organelles * movement of materials within cell * movement of chromosomes during mitosis Cytoplasm in a living cell is never static * cytoskeleton is constantly being taken apart and rebuilt * organelles and vesicles are racing back and forth * can cross the cell in ~ 1 second * unattached proteins moving randomly, but rapidly * can visit every corner of the cell within a few seconds * contents of cytosol are in constant thermal motion Common to all cells: * selectively permeable plasma membrane * genetic code; mechanism of transcription and translation * ATP for the transfer of energy and metabolic pathways Model Organisms 45 Unit 2a – Intro to Cellular Chemistry Most Common Elements in Living Organisms: * C H O N – make up 96% – also P and S are common too * Exist as complex macromolecules and simpler forms like water and carbon dioxide nucleus – dense core in centre, consists of protons and neutrons electrons – continually orbit the nucleus # of protons – defining feature of an element = atomic number – # protons + # neutrons = mass of an atom = mass number – by default, an atom is ‘neutral’, with # protons = # electrons – electrons influence reactivity of an atom †¦ Atomic mass = atomic number + # of neutrons (electrons are neglected because mass is so small) Isotopes – same number of protons but different number of neutrons in the same element Anion – gain electron and are negatively charged Cation – lose electron and are positively charged Outermost ‘valence’ shell influences an atom’s reactivity * electrons in outermost shell valence electrons * unpaired valance electrons determine the number of bonds an atom can make * atoms with filled valance shell = most stable, atoms that are closest to filling are most reactive * elements abundant in organisms have at least one unpaired valence electron Some Definitions: covalent bonds – two or more atoms share pairs of valence electrons * strong bonds of biological systems non-covalent bonds, including * ionic bonds * hydrogen bonds (H-bonds) * hydrophobic interactions olecule – group of atoms held together by energy in a stable association compound – molecule composed of two or more different types of atoms Types of Covalent Bonds * electrons shared ‘equally’ * non-polar covalent bond * can be single (like H2), double (O2) or even triple, depending on number of electrons shared * electrons not shared equally * polar covalen t bond * one of the atoms has a stronger pull on the electrons than the other * pull on electrons = electronegativity * water is the most abundant molecule in biological organisms * human body is ~70% water water as a solvent can dissolve more types of molecules than other molecule known * the polarity of water is key to its role in biology hydrogen bonding – electrical attraction between electronegative atom and partial positive of hydrogen hydrophobic – no affinity for water – â€Å"water fearing† hydrophilic – affinity for water – â€Å"water loving† Acid-base Reaction substance that gives up (donates) protons acid (increases [H+] in solution) substance that accepts protons base (decreases [H+] in solution) chemical reaction that involves transfer of protons acid-base reaction * most olecules act as either an acid or a base * water can be both (both gives up and accepts protons) weak acid: very few molecules dissociated (acetic aci d, water) strong acid: readily gives up protons (hydrochloric acid) when pH = pKa species is 50% ionized Carbon is the most important element in biology carbon atoms give biomolecules their shape but other atoms attached to carbons determine their reactivity * critical H, N, O containing attachments called functional groups *learn orgo functional groups for this course Macromolecules * large, organized molecules that are typically created by polymerization * biological macromolecules (biomolecules) provide the structure and carry out the activities of a cell 4 groups: * carbohydrates(polysaccharides) * lipids(fats) * proteins * nucleic acids * monomers of groups are different – chemical reactions used to make the chains are similar Overview of Macromolecules 3 Proteins – more functions than any other group of macromolecule * enzymes – catalysis; accelerate chemical reactions transport – through cell membranes, in circulation * support – cytoskeleton, fibres of cartilage, hair, nails * signalling / regulatory – hormones, membrane proteins, intracellular messengers * movement- of the cell itself – contractile proteins, flagella – within the cell – motor proteins * defense – antibodies, complement proteins Proteins are Polymers * amino acids are connected in linear polymers of a spe cific sequence * 20 genetically encoded amino acid monomers to pick from * string of amino acids (AAs) = peptide or polypeptide polypeptide folded and coiled into a specific conformation = protein * sometimes 2 or more peptide chains (subunits) combine to form mature, functional protein Amino Acid Structure AAs are ionized under physiological conditions ionization increases solubililty, facilitates interactions with each other and other solutes, increases reactivity (zwitterions) 7 non-ionized ionized R group unique to each AA oxygens tend to pull electrons away, making it easy to lose proton gains a proton Amino Acid Side Chains – R Groups: * nonpolar – hydrophobic R groups no charged or electronegative atoms to form H bonds * insoluble in water * R groups bury themselves with the peptide chain to ‘hide’ from water * polar side chains – soluble in water * uncharged – but partial charges can form H-bonds * charged – groups containing a cids or bases – highly soluble in water AA are linked together by covalent peptide bonds: carbon from carboxyl group is linked to N terminus of amino group. R groups and central C’s do not participate in the bond. Condensation Reaction – making the chain Hydrolysis – breaking the chain Polypeptide chain: side chains extend from peptide-bonded backbone * chain is flexible – can rotate at single bonds on either side of peptide bonds * so side chains are not all projecting to one side! * chains can be from 2-3 to thousands of AAs in length * backbone is directional, convention is to number AA ‘residues’ starting at N terminus this is the primary sequence Sickle Cell Anemia – disease in which red blood cells are abnormally shaped. Caused by single point mutation which results in substitution of single amino acid in one chain of hemoglobin protein Protein Structure: Primary Structure – unique sequence of amino acids Secondary Structure – Folding into elements of structure, hydrogen bonding between amino acids(R groups not involved). 2 shapes: alpha helix and beta pleated sheet(parallel and antiparallel). * learn more Tertiary Structure- interactions of elements of secondary structure forming a global fold, folded into these unique shapes by ionic bonds (electrostatic),hydrogen bonds, disulphide bridges, hydrophobic interaction, van der waals – dipole-dipole(all non-covalent except for S-S). Order of amino acids determines final shape. Maintain globular shape even if very weak. Quaternary Structure – more than one polypeptide chain put together to form the final functional protein, linked by covalent and non-covalent interactions. Protein Domain – segment of polypeptide that forms a compact, stable and independently folding structure. Often the building blocks for larger, more complex proteins. Disulfide bonds * covalent stabilization of protein structure found in secreted proteins (destined for a more hostile extracellular environment) * formed in ER (oxidizing environment) Once folded, do proteins ever unfold? changes in physical or chemical conditions (pH, salt concentration, temperature) disruption of H-bonds, ionic bonds, disulfide bridges, etc that maintain the protein’s shape protein ‘denatures’ or unfolds Possible to renature Do proteins ever fold incorrectly? any mutation that leads to a missing or incorrect amino acid can lead to incorrectly folded protein WHY 32 Possible outcomes: mutation – leads to incorrectly folded protein * protein never functions properly loss of function protein folds properly at first but unfolds under certain conditions eventually loss of function * protein misfolds AND is deposited in insoluble aggregates within cell * loss of function and disruption of other aspects of cell activity * many human diseases now known to be associated with misfolded proteins . Alzheimers, cystic fibrosis, type II diabetes, retinitis pigmentosa, Parkinsons, Creutzfeldt-Jakob, some cancers *read about catalysts and enzymes in Janelle’s notes, page 8-9 Nucleic Acids: Information Polymers * deoxy ribo nucleic acid (DNA) sequence of subunits in DNA polymer directs RNA synthesis * ribo nucleic acid (RNA) * RNA directs ordering of AAs in a peptide chain * information stored as DNA sequences enables living organisms to pass on hereditary information * also allows each cell to pass on hereditary information to the next generation of cells Monomers of Nucleic Acids: Deoxyribo nucleotides – phosphate + deoxyribose + nitrogenous base(A,C, G, or T) Ribo nucleotides – phosphate + ribose + base (A,C,G, or U) Nucleic acids are linear (unbranched) polymers of nucleotides * each nucleotide consists of three parts: * a nitrogenous base a (5-carbon) pentose sugar * a phosphate group Purines = AGPyramidines= C,T and U * Ribose + base = nucleoside * Ribose + base + phosphate = nucleotide Functions of Nucleotides * monomeric units of RNA and DNA * important signal molecules within cells * cyclic adenosine monophosphate (cAMP) * important agents in energy transfer reactions * cleave off phosphate group to release stored energy * act as coenzymes – organic non-protein molecules required for enzyme function * usually adenine-containing nucleotides combined with B vitamins 8 condensation reaction 5’ end – beginning of chain. Chains always built 5’ 3’. Look at above example phosphate group is 5’ 3’ end – where new bases can be added Polymerization rxn’s are endergonic: * making phosphodiester bonds requires energy * energy comes from addition of 2 phosphate groups. * Activated nucleotides = nucleotide triphophates The most famous phosphorylated nucleotide †¦ adenosine triphosphate = ATP 11 adenine 4’ 5’ 5 6 1 2 3 9 4 8 7 1’ 3’ 2’ O P CH2 O O O– P O O O– P O –O O– OH OH O NH2 N N N N ribose adenine + ribose (= adenosine) Secondary Structure of DNA: two strands of DNA align in ‘antiparallel’ arrangement with bases facing inwards. H-bonds form between bases. P P P P P P P P C C G G A A T T P O O O O O O O O O O O C G OH P Note: 3 H-bonds between C and G, 2 between A and T. Only space in the sugar phosphate backbone is for Pyramidine and Purine to bond together. Features of DNA Double Helix * stabilized by H-bonds between complementary bases and hydrophobic interactions between bases * entire molecule water-soluble because charged phosphates backbone face outward * major and minor grooves are significant in regulation of gene transcription Higher Order DNA Structure: DNA molecules can adopt higher order structure – Allows for compact packaging and strict regulation of gene expression RNA vs DNA like DNA: sugar-phosphate backbone covalently linked by phosphodiester bonds * 4 different bases unlike DNA: * uracil (U) instead of thymine (T) * pairing is A-U, C-G * sugar is ribose instead of deoxyribose * hydroxyl group makes ribose much more reactive * RNA is much less stable than DNA Secondary Structure of RNA: like DNA: * H-bonds form between complementary ba se pairs unlike DNA: * most of the time, this base-pairing is between bases on the same strand * leads to formation of ‘stem and loop’ structures with single-stranded regions and double-stranded antiparallel regions * H-bonding is spontaneous, stabilizes the molecule final molecule is single-stranded * Complex folds can result in some RNA having catalytic activity Carbohydrates * Group of molecules that contain carbon, hydrogen and oxygen in a 1:2:1 ratio: (CH2O)n Only monomers are in this ratio, oligomers you lose water * Monomer=monosaccharide * Dimer=disaccharide * Trimer=trisaccharide/oligosaccharide Types: 1. Monosaccharides – simple sugars 2. Oligosaccharides – small chains (oligo=few) * Attached to proteins – glycoproteins * Attached to lipids – glycolipids 3. Polysaccharides – very long sugar chains Typical Structural Features of Sugar Monomers: carbonyl group (either ketone or aldehyde) * lots of -OH groups * vary in length of carbon skeleton (C3, C5, C6, †¦) – triose, pentose, hexose * isomeric forms (glucose, fructose, galactose) * identical chemical groups arranged differently * monosaccharides often form rings in solution Isomers – same atoms, different arrangements structural isomer – identical groups but bonded to different carbons stereo (optical) isomer – identical groups bonded to same carbons but in different orientations sixteen different hexose structures possible, all with formula C6H12O6 C O H C OH OH H C OH H HO C H C O H C OH H H C OH H C OH H C OH H HO C H H C OH H structural isomer stereo- isomer H C C O HO C H H C OH H C OH H HO C H H C OH H fructose glucose galactose *arrangement of hydroxyl groups make a big difference in biological function Disaccharide – 2 sugar monomer: * glucose + fructose = sucrose(table sugar) * glucose + lactose = lactose * glucose + glucose = maltose Formation of disaccharides by condensation reactions. monomers are linked when C1 of one monosaccharide binds to a C on another – often C4 geometry of bond different depending on hether OH group of C1 is in ? or ? position which C of other sugar is involved in linkage 7 C1, ? C4 ?-glucose ?-glucose maltose, ? -1,4 glycosidic bond ?-galactose ?-glucose lactose, ? -1,4 glycosidic bond (glucose has flipped over) C1, ? C4 Polymerization to build Polysaccharides starch both are storage forms for energy starch – plants; glycogen – animals both consist of ? -glucose monome rs linked by ? -1,4 bonds both coil into a helix (due to geometry of linkages) starch is mixture of unbranched amylose and branched amylopectin glycogen is highly branched lycogen Structural Polysaccharide in Plants: Cellulose 9 polymer of ? -glucose, joined by ? -1,4 linkages each glucose is flipped relative to adjacent ones allows for H-bonding between adjacent strands extremely stable most abundant organic molecule on earth parallel strands joined by H-bonds Structural Polysaccharide in Animals: Chitin a component of cell walls of fungi, exoskeletons of arthropods (insects, crustaceans), radulas of molluscs, beaks of cephalopods second most abundant organic molecule on earth like cellulose, joined by ? 1,4 linkages but rather than glucose, monomer is N-acetylglucosamine like cellulose, also strengthened by H-bonding btw strands 10 Structural Polysaccharide in Bacteria: Peptidoglycan component of bacterial cell walls the most complex CHO so far! two different alternating monomers linked by ? -1,4 bonds chain of amino acids attached to one of the sugars – peptide bonds instead of H-bonds (stronger) Significance of how monosaccharides are linked: * ? -1-4 linkages of starch and glycogen readily hydrolyzed * ? 1-4 linkages in structural polysaccharides very resistant to enzymatic degradation For example: enzymes that digest cellulose (cellulase) produced only by certain classes of bacteria, fungi and protozoa Difference between glycosidic bonds from peptide and phosphodiester bonds: in common: * condensation reactions different: * peptide and phosphodiester bonds always occur at the same position within their monomers * each sugar monomer has several hydroxyl groups, and geometry of glycosidic bonds is highly variable Functions of Carbohydrates: Structural: * cellulose, chitin and peptidoglycan Cell-cell recognition: * membrane proteins covalently bonded to oligosaccharides Energy Storage * ? -1,4 –linkages of starch and glycogen are readily hydrolyzed to release stored energy Lipids * group of carbon-containing compounds that are largely non-polar / hydrophobic * significant proportion of a given lipid molecule is hydrocarbon * the only macromolecule that is not a polymer major groups of lipids in cells: * fats / oils – energy storage * sterols * cholesterol – membrane component * steroids – hormones * * Phospholipids * major component of biological membranes Fats (Triacylglycerols, Triglycerides) * form that fat is stores in apidose tissie * glycerol with 3 fatty acids attached * the link between glycerol and fatty acid = ester bond: condenstation rxn (liberates water) * hydrophobic * fatty acid(carboxylic acid with long hydrocarbon tail) Saturated Fatty Acid – have maximum number of hydrogen atoms on each atom; straight and flexible because of only single bonds Unsaturated Fatty Acid – contain at least 1 double bond. The double bond is rigid and creates a kink in the chain. The rest of the chain however is free to rotate about C-C bonds. Cis – H on the same side of double bond; don’t solidify easily Trans – H on the opposite side of the double bond. Hydrogenation – making a fat saturated/more solid at room temperature to improve shelf life therefore less healthy. Sterols – group of steroids based on cholesterol(important component of cell membrane) Phospholipids : * 1 glycerol, 2 fatty acids, 1 phosphate group(polar head group) * Amphipathic = hydrophilic and hydrophilic regions – their most important feature with respect to biology Micelles – sphere with hydrophobic tails ‘hiding’ in centre . Can only occur with relatively short tails Lipid Bilayer: Universal Structure for all Biological Membranes composition varies with: type of organism (prokaryote vs animal vs plant vs †¦) type of cell within organism (muscle, liver, sperm, egg, †¦) type of membrane within cell (plasma membrane, Golgi, ER) inner versus outer layer different patches or ‘domains’ within a particular membrane Fig 11-4 two closely apposed sheets of lipids, studded with proteins lipids serve as permeability barrier proteins perform most of the functions carbohydrates (sugars) attached to protein and lipids in a non-random manner *all membrane lipids are amphipathic Lipid bilayers form spontaneously: hydrophobic molecules would exclude water, clustering together to minimize energy cost of organizing water molecules * form large droplets or surface film * amphipathic molecules are subject to conflicting forces * solved by formation of bilayer * energetically most favourable stable, spontaneous * lipid bilayers are †¦ * closed – no free edges * self-sealing * important feature for cell fusion, budding, locomotion Fluid Mosaic Model * The plasma membrane is described to be fluid because of its hydrophobic integral components such as lipids and membrane proteins that move laterally or sideways throughout the membrane. That means the membrane is not solid, but more like a ‘fluid’. * phospholipids are constantly moving spinning in place; travelling laterally within ‘leaflet’ * phospholipids are occasionally ‘flipped’ to the opposite leaflet during membrane synthesis but they rarely ‘flop’ back * even proteins cruise slowly through the membrane! Membrane fluidity – how easily lipid molecules move within a membrane leaflet Alignment of phospholipid tails * tightly packed tails membrane more viscous, less fluid * freely moving tails higher fluidity What aspects of phospholipid composition influence this? length of fatty acids * from 14-24 carbons, 18-20 carbons most common * degree of saturation of fatty acids # double bonds * typically one saturated fatty acid and one with one or more double bonds Cholesterol: * under physiological conditions, cholesterol makes membrane stiffer – less fluid * cholesterol can make up to 50% of plasma mem brane lipid in some animal cells Regulation of Membrane Fluidity: – fluid state must be maintained for normal cell function strategies for maintaining membrane fluidity: * change composition of membranes * alter phospholipids desaturate fatty acids (to deal with cold) eg cold water vs warm water fish * change length of FA chains (yeast, bacteria) * adjust amounts of cholesterol (animals) these mechanisms have been demonstrated in: * pond fish dealing with dramatic day / night temp differences * cold-resistant plants * extremophile bacteria living in hot springs * winter wheat preparing for autumn ^ polyunsaturated FAs * sperm reduce their cholesterol just before fertilization †¦ Functions of Lipids: * storage of chemical energy * signal molecules * vitamins * wax coating on leaves * biological membranes How to cite Biol 130 First Midterm Notes, Essay examples

The Battle Of Saratoga 2 Essay Research free essay sample

The Battle Of Saratoga 2 Essay, Research Paper The Battle of Saratoga was in all likelihood the most of import conflict of the Revolutionary War. One misconception about this conflict is that it was really two conflicts right following to each other. These conflicts could hold really easy been a glorious British triumph, but the settlers outsmarted them, taking to a singular colonial triumph. Without a uncertainty, these conflicts were the turning point in the war. There are two points of the importance of the American triumph: foremost, it was the greatest triumph for the Americans in the war, and 2nd, France will come in the war on the settler s side. It all started with a really good British program. The British General Gentleman Johnny Burgoyne proposed a program to assail the northern settlements and cut them off from the others. Burgoyne was to take a force coming from Montreal, Canada to Upstate New York, where he would run into up with forces from Barry St. We will write a custom essay sample on The Battle Of Saratoga 2 Essay Research or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Leger, coming from the West, and General Cornwallis coming from the South. They would so environ the settlers and claim triumph. However, as the old expression goes, The best set programs of mice and work forces most frequently go astray. In June, 1777, General Burgoyne set out from Montreal, on his manner to Upstate New York, with an ground forces of stopping point to 7,000 British soldiers, German soldier of fortunes ( besides known as Hessians ) , Loyalists, and Indians. Burgoyne s force proceeded down Lake Champlain and recaptured Fort Ticonderoga on July 5, 1777. After this, he so led his military personnels towards Albany, where he was supposed to run into up with the other two British forces. This well planned out meeting neer took topographic point. The British force led by General St. Leger neer made it to Albany because they were held back by a force of colonial militiamen. They were stuck contending the American ground forces when they should hold been in Albany. The other British force, led by General Cornwallis, was besides drawn off from Albany. As they were traveling north, Cornwallis s military personnels encountered a Continental Army led by General G eorge Washington. Alternatively of go oning north, they followed Washington s military personnels, who went back south. This left the lone British force to contend against a big American force led by General Horatio Gates. The two conflicts of Saratoga were at Freeman s Farm and Bemis Heights, two countries really near to each other. During both of these conflicts, General Gates merely sat back patiently and waited for the aggressive British ground forces to have on themselves out. This was a cagey maneuver. The conflict of Freeman s Farm was fought on September 19, 1777. As a consequence of this conflict, the British had 600 casualties, whereas the Americans merely had 320. The 2nd conflict, the conflict of Bemis Heights, was fought on October 7, 1777. At this conflict, the British had 600 more casualties as opposed to approximately 150 American casualties. Outnumbered and surrounded, Burgoyne reasonably much had no pick but to give up. General Johnny Burgoyne surrendered to the colonial ground forces on October 17, 1777. The Battles at Saratoga were decidedly the turning point in the war. They proved that the American s could win the Revolutionary War, which finally happened. After this conflict, the American forces got stronger for two grounds: France entered the war, and Prussian drillmaster Baron Von Steuben volunteered to assist flog the Continental Army into form. Following Von Steuben s preparation of the soldiers, the Americans looked like a wholly different ground forces. They were now disciplined, every bit good as educated in European combat tactics. I don t think that any of these of import events would hold occurred had non the Americans been winning at Saratoga. I don t even think the Americans would hold won the Revolutionary War if they didn t win in Saratoga. List OF 1 ) Battle of Saratoga, hypertext transfer protocol: //www.spa.net/battle/battle.htm 2 ) Leete Stone, William, Visit to the Saratoga Battle-Grounds, 1780-1880, Associated Faculty, January 1970 3 ) Revolutionary War in America World Book Encyclopedia World Book-Childcraft International, 1982